Phase2 Trial of High Dose Intravenous Ascorbic Acid as an Adjunct to Salvage Chemotherapy in Relapsed/ Refractory Lymphoma, Patients With Clonal Cytopenia of Undetermined Significance, and Chronic Myelomonocytic Leukemia

This study is testing if adding high doses of Vitamin C to standard chemotherapy helps treat certain types of blood cancers and lymphomas that have returned or did not respond to earlier treatments. The goal is to see if Vitamin C can make cancer cells more sensitive, helping the chemotherapy work better at killing them.

This trial is for adults (18+) who have specific types of lymphoma, blood disorders, or bone marrow conditions that have returned or failed to respond to previous therapies. Participants must have a measurable tumor and be healthy enough to receive standard platinum-based chemotherapy.

Participants will receive chemotherapy alongside Vitamin C given through an IV. During the study, you will have regular check-ups, which include blood tests, imaging scans like CTs or MRIs, and potential bone marrow samples to monitor how the cancer is responding.

The study is currently recruiting patients at medical centers in Mankato and Rochester, Minnesota, as well as Eau Claire, Wisconsin. Please speak with your oncologist to see if this trial is a good fit for your specific health situation.