SHARON: Study of Metastatic Cancers in Patients Using Autologous Stems Cells and Potentiated Redox Cycling to Overcome Drug Resistance to Nitrogen Mustard Derivatives

This study is testing a new way to treat advanced breast or pancreatic cancer that has spread to other parts of the body. Researchers want to see if combining specific chemotherapy drugs with vitamins can help overcome cancer's resistance to treatment, giving patients a more effective option.

This trial is for adults aged 18 and older who have Stage IV breast or pancreatic cancer. You must have a life expectancy of at least six months and meet specific health requirements regarding your bile ducts to ensure you are safe to participate.

Participants will undergo two cycles of treatment that include chemotherapy drugs alongside vitamins B12b and C. During the process, your own stem cells will be collected and returned to your body to help your blood-forming system recover after the intensive therapy.

The study is currently recruiting patients at medical centers in Boston, Massachusetts, and New York, New York. Because this is a Phase 1 trial, its main goal is to determine the safety and best dosage of this treatment combination.