MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK)

This study compares two different approaches for patients with small-cell lung cancer to see if closely monitoring the brain with MRI scans alone works as well as giving preventative brain radiation. The goal is to see if skipping preventative radiation can help patients avoid side effects while living a full life.

You might be eligible if you have been diagnosed with small-cell lung cancer, have finished your initial treatments successfully, and a recent brain MRI shows no cancer has spread to your brain. Your doctor will also need to confirm that your previous treatments worked and that side effects from them have mostly improved.

Depending on the group you are placed in, you will either receive regular brain MRI scans to monitor your health or receive both MRI scans and preventative brain radiation therapy. Researchers will track your health over time to see how each approach works for you.

This study has locations in places like Alabama and Alaska in the United States. It is currently active, meaning it is underway, though it is not actively looking for new participants right now.