PEACH TRIAL- Precision mEdicine and Adoptive Cellular tHerapy for the Treatment of Recurrent Neuroblastoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG)

This study is testing a new personalized treatment for children fighting tough-to-treat brain tumors called DIPG or a nerve cancer called neuroblastoma. It combines specially trained immune cells from the patient's own body with targeted therapies to see if this approach is safe and helpful.

This trial is designed for children over 12 months old with high-risk neuroblastoma or DIPG whose cancer has returned or stopped responding to standard treatments. Participants must also have generally healthy major organs and no active immune disorders.

Participants will receive treatments using their own white blood cells, which are collected, grown in a lab to fight their specific cancer, and then given back to them. The medical team will closely monitor the child's safety and check how their body responds to the therapy.

This study is currently recruiting patients and takes place at medical centers in Gainesville, Florida, Charlotte, North Carolina, and Hershey, Pennsylvania.