A Phase II Study of Pembrolizumab, Olaparib, and Temozolomide in Patients With Glioma

This study is testing a combination of three different cancer drugs to see if they can effectively treat gliomas, which are tumors in the brain or spinal cord. The goal is to see if using these medications together can better fight cancer that has returned or stopped responding to previous treatments.

This study is open to adults with specific types of gliomas that have returned after initial treatments like surgery or radiation. You will need to have genetic testing on your tumor, be on a stable low dose of steroids, and be in good enough health to safely receive the treatment.

Participants will receive a combination of immunotherapy to boost the immune system and two types of medications that work together to prevent cancer cells from repairing themselves. You will be closely monitored by a medical team to track how the treatment affects your tumor and your overall health.

The study is currently recruiting patients at locations in Hartford, Connecticut; Miami, Florida; and Basking Ridge, New Jersey. Please speak with your doctor or the study coordinator to see if a location near you is the right fit.