Phase I Study -To Assess Safety and Feasibility of IL-8 Receptor Modified Patient-derived Activated CD70 CAR T Cell Therapy in CD70+ Adult GBM and Pediatric High-Grade Gliomas (pHGG)

This study is testing a new type of treatment for aggressive brain tumors called glioblastoma. Researchers are using a patient's own immune cells, modified in a lab to better find and attack cancer, to see if this approach is safe and helpful.

This study is for adults over 18 who have been newly diagnosed with a specific type of brain tumor. To join, your tumor must have a protein called CD70, and you must have already had surgery to remove most of the tumor.

Doctors will collect some of your immune cells, modify them in a laboratory to fight the cancer, and then return them to your body. You will be closely monitored by the medical team throughout the process to track how you respond to the therapy.

This study is currently recruiting new participants and is located in Gainesville, Florida. Please speak with your doctor to see if this center is the right fit for your care needs.