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Recruiting

Clinical Trial of CD40L-augmented Tumor Infiltrating Lymphocytes (CD40L TIL) for Patients With Oncogene-Driven Advanced Non-Small Cell Lung Cancer (NSCLC)

What is this study?

This study is testing a new way to help your immune system fight advanced lung cancer that has a specific genetic change. By growing your own immune cells in a lab and returning them to your body, researchers hope to find a more effective way to stop the cancer from growing.

Who can participate?

This trial is for adults (18+) with advanced lung cancer that has spread or returned despite previous treatments. Participants must have specific genetic markers like EGFR, ALK, ROS1, or HER2 and be generally active enough to handle the treatment.

What will happen?

You will receive chemotherapy to prepare your body, followed by an infusion of your own immune cells that have been boosted in a lab, plus an immune-boosting medication called nivolumab. You will be closely monitored by a team of experts throughout the process to ensure your safety.

Where and when?

The study is currently recruiting patients and is taking place in Tampa, Florida. Your medical team can help you decide if this location is a good fit for you.

Key Points
  • 1Uses your own immune cells (called TILs) to help attack your cancer.
  • 2Specifically designed for lung cancers with certain genetic changes.
  • 3Includes a comprehensive care team to monitor you before, during, and after treatment.

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Conditions Studied
This study is investigating treatments for the following conditions
Non Small Cell Lung CancerStage IV Non-small Cell Lung CancerRecurrent Non Small Cell Lung Cancer

This summary was generated using AI and may not capture all details. Always consult with a healthcare professional for medical advice.