A Feasibility Study Examining the Use of Non-Invasive Focused Ultrasound (FUS) With Oral Etoposide Administration in Children With Progressive Diffuse Midline Glioma (DMG)
This study is testing a new way to deliver chemotherapy directly to hard-to-reach brain tumors called diffuse midline gliomas. By using sound waves to temporarily open a protective barrier around the brain, doctors hope to help medicine reach the tumor more effectively while reducing side effects.
This trial is for children and young adults aged 4 to 21 who have been diagnosed with a specific type of progressive brain tumor. Participants must be generally healthy enough to undergo the procedures and meet specific criteria regarding their physical activity levels.
Participants will take a chemotherapy medicine called etoposide by mouth. They will also receive a non-invasive procedure where sound waves, guided by specialized mapping technology, are used to safely and temporarily open the barrier around the brain tumor site.
The study is currently recruiting participants and is located in New York, New York.
- 1Uses non-invasive sound waves to help chemotherapy reach the tumor better.
- 2Specifically for patients aged 4-21 with progressive midline glioma tumors.
- 3Focuses on improving treatment delivery while aiming to lower overall side effects.
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