A Phase 1 Study of 5-Fluorouracil in Combination With Abemaciclib in Metastatic, Refractory CRC
This study is testing a new combination of two cancer drugs to see if they can effectively slow down or stop the growth of advanced colorectal cancer. It is specifically for patients whose cancer has not responded well to standard treatments and is looking for a new way to fight these tumors.
This trial is for adults (18+) with metastatic colorectal cancer that has a specific genetic pattern called 'microsatellite stable.' You must have tried standard treatments before and be physically capable of performing your daily activities.
Participants will receive a combination of the drug Abemaciclib and chemotherapy (5-fluorouracil). You will also have regular check-ups that include blood tests, tissue samples, and imaging scans like CTs or MRIs to monitor how your body is responding.
This study is currently recruiting patients at medical centers in Irvine and Orange, California, as well as the Bronx, New York.
- 1The goal is to find a safe and effective dose of these drugs when taken together.
- 2The study focuses on patients who have already tried other common treatments without success.
- 3Participation includes regular health monitoring through scans and lab work.
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