A Phase I Trial Combining Triapine With Radiation Therapy for Recurrent Glioblastoma or Astrocytoma

This study is testing a new way to treat brain tumors that have returned after previous care. By combining a medication called Triapine with radiation therapy, researchers hope to stop cancer cells from growing and repairing themselves.

This trial is for adults with specific types of recurring brain tumors, such as glioblastoma or astrocytoma, that have certain genetic markers. Participants must have fully recovered from previous treatments and meet specific health requirements regarding their blood and overall medical history.

You will receive both radiation therapy and the drug Triapine while being closely monitored by a medical team. Throughout the study, you will have regular check-ups, blood tests, and imaging scans like MRIs to see how your body and the tumor respond to the treatment.

The study is currently recruiting patients at locations in Duarte, Irvine, and La Jolla, California. Because this is a Phase I trial, its main goal is to find the safest dose for patients.