A Phase 1, Multicenter Trial of Subcutaneous Trastuzumab Deruxtecan in Participants With Metastatic Solid Tumors

This study is testing a new way to give a cancer-fighting medicine called Trastuzumab Deruxtecan by injecting it under the skin rather than through an IV. The goal is to see if this method is safe and effective at treating solid tumors that have spread to other parts of the body.

This study is for adults aged 18 or older who have metastatic cancer with a known HER2 protein status. Participants generally need to have tried previous treatments for their specific type of cancer and must meet certain heart and lung health requirements to ensure it is safe for them to take part.

Participants will receive the study medication via a subcutaneous injection, which is a shot given just under the skin. Throughout the process, the research team will monitor you closely to check your health, track how your body responds to the drug, and ensure you are feeling as well as possible.

The study is currently recruiting volunteers at medical centers in Newport Beach, California; Atlanta, Georgia; and Las Vegas, Nevada. Since it is actively recruiting, you can talk to your doctor to see if one of these locations is an option for you.