A Randomized Phase II Study of Consolidative Surgery and Radiotherapy With Curative Intent for De Novo Oligometastatic HER2+ Breast Cancer [Ablation and Resection for the Consolidation of Oligometastatic HER2+ Breast Cancer (ARCHER)]

This study is testing if adding surgery and focused radiation to standard cancer treatment can better control breast cancer that has spread to just a few spots. By treating these specific areas, researchers hope to see if they can improve long-term health outcomes for patients with HER2-positive breast cancer.

This study is for adults with HER2-positive breast cancer that has spread to five or fewer locations outside the breast. To join, these spots must be safe to treat with surgery or radiation, and the cancer must not have spread to the brain or spinal cord.

Participants will receive standard anti-cancer medications and may undergo surgery or high-energy radiation therapy to target the cancer spots. The research team will closely monitor you throughout the process to track how well the treatment works and manage any potential side effects.

The study is currently recruiting patients at three locations in New Jersey. Your medical team will help determine if the trial is a good fit for your specific health situation.