TBCRC Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies (EVOLVE-BDT)

This study looks for better ways to treat metastatic breast cancer by using a person's specific tumor 'biomarkers'—the unique biological signals inside their cancer cells. By matching patients to treatments that target these signals, researchers hope to find more effective, personalized options for managing the disease.

This trial is for adults 18 or older with specific types of metastatic breast cancer who are still able to carry out their daily activities. You must be able to follow the study schedule and have a tumor location that is safe for doctors to biopsy.

You will receive treatments tailored to your cancer's unique markers, which may include hormone-blocking drugs or chemotherapy. Throughout the study, you will have regular medical exams, imaging tests, and 'liquid biopsies' (simple blood tests) to see how your body and the cancer are responding to the medicine.

The study is currently recruiting patients at medical centers in New Haven, Connecticut; Baltimore, Maryland; and Rochester, Minnesota. You should talk to your doctor to see if one of these locations is an option for you.