Intensified Adjuvant Therapy for High-Risk Newly Diagnosed Glioblastoma With Subtotal Resection or Short-Term Progression: A Prospective, Single-Arm Phase II Clinical Study

This study is testing a new, more intense treatment plan for people with a high-risk type of brain tumor called glioblastoma. The goal is to see if combining stronger radiation with specific medications can better control the tumor and help people live longer.

This trial is for adults (18+) who have been diagnosed with glioblastoma where either only part of the tumor could be removed or the tumor has shown signs of growing back shortly after surgery. You must also have generally healthy organ function and be able to commit to the study’s regular check-up schedule.

You will receive a combination of standard chemotherapy and specialized radiation, alongside two additional medications that help your immune system fight the cancer and starve the tumor of its blood supply. Throughout the year-long treatment, you will have frequent health check-ups, blood tests, and brain scans to monitor your safety and how well the treatment is working.

The study is currently recruiting participants and is taking place in Hangzhou, Zhejiang, China.